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Phosphaturic mesenchymal tumor: A chondromyxoid fibroma‐like type.

Authors :
Koga, Kaori
Iwasaki, Hiroshi
Nabeshima, Kazuki
Source :
Journal of Dermatology; Nov2023, Vol. 50 Issue 11, p1484-1487, 4p
Publication Year :
2023

Abstract

Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm that causes tumor‐induced osteomalasia (TIO) in most affected patients, usually through the production of fibroblast growth factor 23 (FGF23). This tumor is often misdiagnosed due to its relative rarity and its widely varied histomorphologic spectrum. Here we describe a case of a 78‐year‐old woman who presented with a left middle tumor without symptoms of TIO. The histological features resembled chondromyxoid fibroma with smudgy calcification in the tumor matrix. In addition, we evaluated FGF23 expression through immunohistochemical study and reverse transcription polymerase chain reaction. PMT with chondromyxoid fibroma features are extremely rare. Examining the expression of FGF23 is useful in the diagnosis of PMT. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03852407
Volume :
50
Issue :
11
Database :
Complementary Index
Journal :
Journal of Dermatology
Publication Type :
Academic Journal
Accession number :
173439246
Full Text :
https://doi.org/10.1111/1346-8138.16870