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Regeneration of taste through sonic hedgehog upregulation by photobiomodulation.
- Source :
- Journal of Biophotonics; Nov2023, Vol. 16 Issue 11, p1-10, 10p
- Publication Year :
- 2023
-
Abstract
- This study investigated photobiomodulation (PBM) effects in Sonic hedgehog (Shh) signaling as a potential approach to taste preservation and regeneration. Primary taste cell (TC) cultures were treated with Shh antagonist vismodegib and irradiated using a continuous wave type 630 nm light‐emitting diode (10 mW/cm2) array, with single or multiple doses of 30 J/cm2 to determine dose inducing significant upregulation effect. Shh, Ptch, Smo, and Gli1 were significantly upregulated at 120 J/cm2, used as the minimum dose in vivo. Vismodegib was administered via daily oral gavage for 21 days (30 mg/kg) to induce Shh inhibition in the tongue of rat animal models resulting in taste bud damage and taste dysfunction. PBM treatment using a 630 nm laser (3 W/cm2) at a radiant exposure of 120 J/cm2 (24 J/cm2 × 5) successfully upregulated the Shh protein expression, regenerated taste buds, and recovered taste function. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1864063X
- Volume :
- 16
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Biophotonics
- Publication Type :
- Academic Journal
- Accession number :
- 173396880
- Full Text :
- https://doi.org/10.1002/jbio.202300043