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Unraveling the multifaceted molecular interactions of HPV E6 in carcinogenesis.

Authors :
Letafati, Arash
Ardekani, Omid Salahi
Jazayeri, Seyed Mohammad
Ghaziasadi, Azam
Sakhavarz, Tannaz
Soleimani, Mina
Goldoost, Yeganeh
Norouzi, Mehdi
Source :
Current Research in Medical Sciences; 2023, Vol. 7 Issue 2, p58-70, 13p
Publication Year :
2023

Abstract

Background: Human Papillomaviruses (HPVs) are common sexually transmitted viruses that cause health problems, including genital warts and different type of cancers. There are over 200 different types of HPV, some of which are correlated with the progress of cervical cancer. One of the HPV genes responsible for its oncogenic potential is the E6 gene. E6 is a critical protein in the life cycle of HPV and a key contributor to the development of HPV-associated cancers. Its interactions with cellular proteins lead to disruptions in key cellular pathways and the promotion of cancerous cell growth. Overall, HPV E6 represents a reassuring target for the expansion of novel therapies for the treatment of HPV-associated cancers and understanding its molecular interactions with host proteins is critical for developing targeted therapies for HPV-associated cancers. In this article, we will focus on the cancer-related mechanism and cell interaction of HPV E6. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
25386212
Volume :
7
Issue :
2
Database :
Complementary Index
Journal :
Current Research in Medical Sciences
Publication Type :
Academic Journal
Accession number :
173355251
Full Text :
https://doi.org/10.22088/crms.7.2.58