Back to Search Start Over

Engineering Non-Human RNA Viruses for Cancer Therapy.

Authors :
Tur-Planells, Vicent
García-Sastre, Adolfo
Cuadrado-Castano, Sara
Nistal-Villan, Estanislao
Source :
Vaccines; Oct2023, Vol. 11 Issue 10, p1617, 22p
Publication Year :
2023

Abstract

Alongside the development and progress in cancer immunotherapy, research in oncolytic viruses (OVs) continues advancing novel treatment strategies to the clinic. With almost 50 clinical trials carried out over the last decade, the opportunities for intervention using OVs are expanding beyond the old-fashioned concept of "lytic killers", with promising breakthrough therapeutic strategies focused on leveraging the immunostimulatory potential of different viral platforms. This review presents an overview of non-human-adapted RNA viruses engineered for cancer therapy. Moreover, we describe the diverse strategies employed to manipulate the genomes of these viruses to optimize their therapeutic capabilities. By focusing on different aspects of this particular group of viruses, we describe the insights into the promising advancements in the field of virotherapy and its potential to revolutionize cancer treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2076393X
Volume :
11
Issue :
10
Database :
Complementary Index
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
173338917
Full Text :
https://doi.org/10.3390/vaccines11101617