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Functional involvement of urokinase-type plasminogen activator receptor in pemphigus acantholysis.
- Source :
- Journal of Cutaneous Pathology; Oct1998, Vol. 25 Issue 9, p469-474, 6p, 4 Color Photographs, 1 Diagram
- Publication Year :
- 1998
-
Abstract
- Urokinase-type plasminogen activator (uPA) has been well documented in the development of pemphigus acantholysis. The function of its receptor (uPA-R) in pemphigus acantholysis has only recently attracted attention. Increased expression of uPA-R has been demonstrated in pemphigus vulgaris. In this study, we have further explored the functional involvement of uPA-R in pemphigus acantholysis. Our results show that uPA-R expression is significantly increased in acantholytic foci of pemphigus vulgaris and pemphigus foliaceus but not in bullous pemphigoid or normal skin specimens; the expression of uPA-R in cultured human keratinocytes is subjected to regulation by pemphigus vulgaris IgG but not by pemphigoid IgG or normal human IgG; furthermore, anti-uPA-R monoclonal antibody effectively inhibits pemphigus vulgaris IgG induced acantholysis in skin organ cnltures. These data suggest that uPA-R may play an important role in the pathogenesis of pemphigus acantholysis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03036987
- Volume :
- 25
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Cutaneous Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 17304739
- Full Text :
- https://doi.org/10.1111/j.1600-0560.1998.tb01777.x