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Dehydration of Amides by Redox‐Active Phenalenyl Based Mn‐Catalyst.
- Source :
- ChemCatChem; 10/6/2023, Vol. 15 Issue 19, p1-9, 9p
- Publication Year :
- 2023
-
Abstract
- A redox‐active phenalenyl ligand coordinated Mn(III)‐complex can be reduced chemically to generate an active catalyst containing a ligand‐centered radical. This chemically reduced Mn‐catalyst shows excellent catalytic reactivity for silylative dehydration of a wide range of primary amides (including late‐stage diversification of various bio‐active molecules) to synthesize nitriles using an inert and inexpensive silane, polymethylhydrosiloxane (PMHS), under mild conditions. Control experiments suggest a radical pathway for the present catalytic reaction, initiated by the ligand‐centered radical. [ABSTRACT FROM AUTHOR]
- Subjects :
- DEHYDRATION
AMIDES
RADICALS (Chemistry)
NITRILES
CATALYSTS
Subjects
Details
- Language :
- English
- ISSN :
- 18673880
- Volume :
- 15
- Issue :
- 19
- Database :
- Complementary Index
- Journal :
- ChemCatChem
- Publication Type :
- Academic Journal
- Accession number :
- 172894046
- Full Text :
- https://doi.org/10.1002/cctc.202300462