ortho -Heterobimetallic Arylene Complex: A New Platform for Regioselective Difunctionalization.

This article discusses the synthesis of ortho-heterobimetallic arylene compounds and their potential applications in regioselective difunctionalization (ODF) in organic chemistry. The authors explore the challenges of incorporating two functional groups onto adjacent carbons of an aromatic ring and propose the use of 1,2-arylene heterobimetallic intermediates containing one or two transition metals as a versatile tool for ODFs. They demonstrate the successful synthesis of these heterobimetallic compounds using Fe/Ti synergism and show their ability to achieve both regioselective E/E' and Nu/E ODFs. The authors also highlight the potential applications of these compounds in the synthesis of natural products and drugs. [Extracted from the article]