Risk factors of extubation failure in neurocritical patients with the most impaired consciousness.

More than 20 years ago, Coplin et al. [[3]] described that the extubation failure rate was similar in patients with or without impaired consciousness [[3]], suggesting that impaired consciousness is not incompatible with extubation attempt. In this subgroup, the extubation failure rate was 25.9% (90 patients) and was significantly higher than in patients with preserved consciousness (19.6%, I p = i 0.02). We performed a post hoc analysis of the ENIO study [[2]], to identify the risk factors associated with extubation failure in patients with the most impaired level of consciousness, defined as a mGCS <= 5 on the day of extubation. [Extracted from the article]