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Neoadjuvant endocrine therapy in ER-positive breast cancer: evolution, indication, and tailored treatment strategy.

Neoadjuvant endocrine therapy in ER-positive breast cancer: evolution, indication, and tailored treatment strategy.

Authors :
Jeong, Hyehyun
Kim, Sung-Bae
Source :
Therapeutic Advances in Medical Oncology; 9/29/2023, p1-19, 19p
Publication Year :
2023

Abstract

In recent years, endocrine therapy (ET), an effective systemic treatment for the management of estrogen receptor (ER)-positive breast cancers, has regained interest as a neoadjuvant therapy based on evidence that ET can fulfill the aim of neoadjuvant systemic treatment for tumor shrinkage as well as elucidate important clinical information on endocrine sensitivity that enables the prognostication of patients. Moreover, neoadjuvant endocrine therapy (NET) potentially provides an opportunity for early assessment of the clinical efficacy of novel agents. Furthermore, recently reported trials have generated evidence for a more tailored approach for perioperative management of ER-positive breast cancer using clinical and molecular biomarkers, and this has provided a rationale that enables the broadening of clinical indications for NET. This review discusses the current evidence for NET, the evolution of NET trials, clinical indications, and NET-based treatment strategies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17588340
Database :
Complementary Index
Journal :
Therapeutic Advances in Medical Oncology
Publication Type :
Academic Journal
Accession number :
172447176
Full Text :
https://doi.org/10.1177/17588359231200457