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Synthesis of 4-Phenylpyrrolidone Derivatives with Anticonvulsant and Nootropic Activity.
- Source :
- Pharmaceutical Chemistry Journal; Aug2019, Vol. 53 Issue 5, p429-435, 7p
- Publication Year :
- 2019
-
Abstract
- New 4-phenylpyrrolidone derivatives were designed from racetam structures that combine nootropic and anticonvulsant activity. The proposed compounds were synthesized using 4-phenylpyrrolidone and aromatic amines. The anticonvulsant activity of the new compounds was studied. The structure–activity relationship was analyzed. The most active compound was the 2,6-dimethylanilide of (2-oxo-4-phenylpyrrolidin-1-yl)acetic acid at doses of 2.5 – 5.0 mg/kg, which surpassed the reference drug levetiracetam at doses of 2.5 – 600 mg/kg in all tests and possessed distinct nootropic activity that was comparable to that of the reference nootropic drug piracetam at a dose of 400 mg/kg. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0091150X
- Volume :
- 53
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Pharmaceutical Chemistry Journal
- Publication Type :
- Academic Journal
- Accession number :
- 172438963
- Full Text :
- https://doi.org/10.1007/s11094-019-02015-x