Development and Study of Anxiolytic Effect of Gml-1 Tablet Dosage Form.

Authors :: Yarkova, M. A.
Blynskaya, E. V.
Yudina, D. V.
Mokrov, G. V.
Gudasheva, T. A.
Alekseev, K. V.
Source :: Pharmaceutical Chemistry Journal; Jul2019, Vol. 53 Issue 4, p342-346, 5p
Publication Year :: 2019
Abstract: Novel pyrrolo[1,2-a]pyrazine ligands of 18-kDa translocator protein (TSPO) were synthesized at Zakusov Research Institute of Pharmacology. Pharmacological studies of drug substance N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (GML-1) were consistent with high affinity for TSPO and significant anxiolytic activity. A finished dosage form of GML-1 drug substance was developed and exhibited pronounced anxiolytic activity after intragastric administration over a wide dose range. [ABSTRACT FROM AUTHOR]