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Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia: Study of a Cohort of Patients from a Single Italian Center.
- Source :
- Children; Sep2023, Vol. 10 Issue 9, p1457, 11p
- Publication Year :
- 2023
-
Abstract
- Testicular adrenal rest tumors (TARTs) are a common complication in male patients with congenital adrenal hyperplasia (CAH). The aim of our cross-sectional cohort study is to estimate the frequency of TARTs with the correlation of genotype and disease control on tumor development. Thirty-five male patients, aged 14–26 years, were included in the study, all followed by the same center of pediatric endocrinology in Bologna. We studied genotypes, hormonal profiles at different time intervals and testicular ultrasound. A logistic regression model with multivariant analysis was developed for the statistical analysis. TARTs were detected in 31.4% of the cases, 90.9% of them had a classic form with salt wasting, while 9.1% had a non-classic form. Additionally, a significant correlation between the incidence of TARTs and severity of genotype was detected. Patients with TARTs had markedly worse metabolic control on average (p = 0.027), reflected by high ACTH, 17OH progesterone, and overall delta4-androstenedione. In conclusion, a screening tool is mandatory, especially (but not exclusively) in patients with the most severe forms of CAH and poor endocrine control of the disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- ADRENOGENITAL syndrome
ADRENAL diseases
DISEASE progression
RESEARCH
ENDOCRINOLOGY
STATISTICS
ULTRASONIC imaging
PROGESTERONE
TESTICULAR diseases
CROSS-sectional method
MULTIPLE regression analysis
MULTIVARIATE analysis
SEX differentiation disorders
PEDIATRICS
RETROSPECTIVE studies
FISHER exact test
MANN Whitney U Test
RISK assessment
T-test (Statistics)
DESCRIPTIVE statistics
CHI-squared test
STATISTICAL correlation
ANDROSTENEDIONE
DATA analysis software
GENETIC profile
LONGITUDINAL method
DISEASE risk factors
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 22279067
- Volume :
- 10
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Children
- Publication Type :
- Academic Journal
- Accession number :
- 172392971
- Full Text :
- https://doi.org/10.3390/children10091457