The role of CD91 and heat shock proteins in psoriasis.

The article focuses on the role of CD91 and heat shock proteins in psoriasis. Heat shock proteins (HSPs) have an enormous significance in the dynamic interplay between innate and adaptive immunity and provides new insights into mechanisms underlying chronic inflammation, including the necrotic response to infection and cancer. The history of this particular story began with chance events in 1962 when the temperature on an incubator full of fruit flies was inadvertently turned up to 60 degrees Celsius. Under light microscopy, the salivary gland chromosomes of the fruit flies, thus 'heat-shocked', showed dilated puffs indicative of transcriptional activity at discrete loci.