Line‐field confocal optical coherence tomography and reflectance confocal microscopy of Merkel cell carcinoma.

Given these premises, LC-OCT appears to be very useful in the differential diagnosis of MCC. RCM en-face (c) and LC-OCT horizontal sections (d) showing hyporeflective nests (red circle) of monomorphous cells (red asterisks) outlined by bright collagen septa (yellow arrows). Line-field confocal optical coherence tomography, thanks to its cellular resolution, its depth of penetration and its tridimensional view, seems to be very useful for the early diagnosis of MCC, allowing it to be differentiated from other clinically and dermoscopically similar tumours. [Extracted from the article]