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Research priorities regarding the use of bisphosphonates for osteoporosis: a UK priority setting exercise.
- Source :
- Osteoporosis International; Oct2023, Vol. 34 Issue 10, p1711-1718, 8p, 1 Black and White Photograph, 2 Diagrams, 1 Chart
- Publication Year :
- 2023
-
Abstract
- Purpose: Worldwide, many people who would benefit from osteoporosis drugs are not offered or receiving them, resulting in an osteoporosis care gap. Adherence with bisphosphonates is particularly low. This study aimed to identify stakeholder research priorities relating to bisphosphonate treatment regimens for prevention of osteoporotic fractures. Methods: A three-step approach based on the James Lind Alliance methodology for identification and prioritisation of research questions was used. Research uncertainties were gathered from a large programme of related research studies about bisphosphonate regimens and from recent published international clinical guidelines. Clinical and public stakeholders refined the list of uncertainties into research questions. The third step prioritised the questions using a modified nominal group technique. Results: In total, 34 draft uncertainties were finalised into 33 research questions by stakeholders. The top 10 includes questions relating to which people should be offered intravenous bisphosphonates first line (1); optimal duration of treatment (2); the role of bone turnover markers in treatment breaks (3); support patient need for medicine optimisation (4); support primary care practitioner need regarding bisphosphonates (5); comparing zoledronate given in community vs hospital settings (6); ensuring quality standards are met (7); the long-term model of care (8); best bisphosphonate for people aged under 50 (9); and supporting patient decision-making about bisphosphonates (10). Conclusion: This study reports, for the first time, topics of importance to stakeholders in the research of bisphosphonate osteoporosis treatment regimens. These findings have implications for research into implementation to address the care gap and education of healthcare professionals. Summary: Using James Lind Alliance methodology, this study reports prioritised topics of importance to stakeholders in the research of bisphosphonate treatment in osteoporosis. The priorities address how to better implement guidelines to address the care gap, understanding patient factors influencing treatment selection and effectiveness, and how to optimise long-term care. [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG therapy
BONE fracture prevention
OSTEOPOROSIS prevention
RESEARCH
MEDICAL quality control
RESEARCH evaluation
DIPHOSPHONATES
INTRAVENOUS therapy
PRIORITY (Philosophy)
ATTITUDES of medical personnel
STAKEHOLDER analysis
PATIENT decision making
UNCERTAINTY
TREATMENT duration
OSTEOPOROSIS
MEDICAL protocols
PUBLIC opinion
LONG-term health care
DISEASE complications
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 0937941X
- Volume :
- 34
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Osteoporosis International
- Publication Type :
- Academic Journal
- Accession number :
- 172041223
- Full Text :
- https://doi.org/10.1007/s00198-023-06806-7