Microneedle-mediated polydeoxyribonucleotide nanoliposomes for skin penetration performance and anti-aging efficacy.

The skin penet rat ion proper t ies and skin ant i-aging eff icacy of microneedle-mediated t ransdermal delivery of polydeoxyribonucleotide nanoliposomes (PDRN-NLPs) were investigated. The particle size of PDRN-NLPs was (50.1 ± 0.2) nm, the PDI was 0.267 ± 0.008, and the Zeta potential was (-30.2 ± 0.8) mV. The nanoliposomes, mediated by the microneedles, could effectively facilitate the rapid penetration of active ingredients into the skin. Cellular anti-aging efficacy studies showed that PDRN-NLPs significantly increased SOD activity, significantly increased GSH content and significantly decreased MDA level compared with the free component solution (P < 0.05 or P < 0.01). It significantly increased the secretion levels of Col I, Col III and HA (P < 0.05 or P < 0.01). [ABSTRACT FROM AUTHOR]