The Role of Serum Glutathione Peroxidase Enzyme in Relapsing-Remitting Multiple Sclerosis.

Background: Multiple sclerosis (MS) is considered an immune-mediated disorder with different disease course., Recently, oxidative stress was reported to play a role in the pathogenesis of MS. Aim: to investigate the role of the serum glutathione peroxidase enzyme in the pathogenesis of Multiple sclerosis, especially the relapsing-remitting type (RRMS), and to assess the relationship between it and disease characteristics. Methods: 45 patients with RRMS (23 in relapse and 22 in remission) (18 males and 27 females) and 45 age, sex, and body mass index (BMI)-matched healthy subjects were included in this study. Clinical assessment, general, and neurological examination were done. MS Severity was calculated using the expanded disability status scale (EDSS). Magnetic resonance imaging (MRI) of the brain and spine with gadolinium enhancement and visual evoked potential was done for all MS patients. Serum glutathione peroxidase (GPX) enzyme and routine laboratory tests were assessed. Results: reduced levels of GP in patients compared to controls. No significant difference was detected between the remitting and relapsing MS groups. In addition, there was a statistically significant negative correlation between serum GPx, disease duration, and physical MSIS. Also, an adverse correlation between serum GPx and gadolinium enhancement was recorded. Conclusion: Our study demonstrates a significantly lower level of GPX among patients than among controls; this indicates its role in MS pathogenesis, which might be important for new therapeutic strategies based on an antioxidant approach in MS patients. [ABSTRACT FROM AUTHOR]