Back to Search Start Over

Recent advances on nerve guide conduits based on textile methods.

Authors :
Shihan Gao
Xiangshang Chen
Beining Lu
Kai Meng
Ke-Qin Zhang
Huijing Zhao
Source :
Smart Materials in Medicine; 2023, Vol. 4, p368-383, 16p
Publication Year :
2023

Abstract

Peripheral nerve injury (PNI) is a common and complex clinical disease with high morbidity, limited treatment options and poor clinical outcomes. Several million cases of PNI in the world every year have brought a heavy burden to the patients and the social economy. Autologous nerve grafting has long been the "gold standard" in the treatment of PNI repair, but it still has some shortcomings, such as donor area injury, limited graft source and mismatch of nerve thickness after transplantation. In recent years, many artificial nerve guidance conduits (NGCs) have emerged for replacing autologous nerve grafts, and their effectiveness has been proven. Currently, there are already clinical products obtained from the European CE Certification, and approved by the Food and Drug Administration (FDA), China Food and Drug Administration (CFDA), Therapeutic Goods Administration (TGA) in Australia, etc. The preparation of NGCs requires interdisciplinary studies and has received considerable attention from researchers in recent years. At present, among emerging and mature manufacturing technologies, textile methods to prepare NGCs are relatively simple and have wide material sources, which has become a hotspot in textile research. This paper mainly reviewed the current situation and recent technological achievements of NGCs that were prepared by textile methods. Several other common methods were also briefly summarized. Furthermore, current NGCs products and their clinical applications were reported. Finally, the future development direction of textile-based NGCs is discussed in this review. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
25901834
Volume :
4
Database :
Complementary Index
Journal :
Smart Materials in Medicine
Publication Type :
Academic Journal
Accession number :
171927232
Full Text :
https://doi.org/10.1016/j.smaim.2022.12.001