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The association between dietary quality scores with C-reactive protein and novel biomarkers of inflammation platelet-activating factor and lipoprotein-associated phospholipase A2: a cross-sectional study.
- Source :
- Nutrition & Metabolism; 9/12/2023, Vol. 20 Issue 1, p1-13, 13p
- Publication Year :
- 2023
-
Abstract
- Healthy dietary patterns are associated with lower inflammation and cardiovascular disease (CVD) risk and adherence can be measured using diet quality scores. Inflammation is traditionally measured with C-reactive protein (hsCRP), however there is interest in novel pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A2 (Lp-PLA<subscript>2</subscript>) that are specifically involved in endothelial dysfunction and inflammation. This cross-sectional study investigated the association between PAF, Lp-PLA<subscript>2</subscript>, hsCRP, and six diet scores. One hundred adults (49 ± 13 years, 31% male) with variable CVD risk were recruited. Fasting PAF, Lp-PLA<subscript>2</subscript> and hsCRP and usual dietary intake were measured. Adherence to Dietary Approaches to Stop Hypertension (DASH), Dairy-adjusted DASH, Vegetarian Lifestyle Index, Healthy Eating Index for Australians (HEIFA), Mediterranean Diet Adherence Screener (MEDAS) and PREDIMED-Plus (erMedDiet) scores were calculated. Correlations and multiple regressions were performed. hsCRP, but not PAF, independently correlated with several diet scores. Lp-PLA<subscript>2</subscript> independently correlated with Vegetarian Lifestyle Index only in unadjusted models. A one-point increase in adherence to the DASH Index, the Dairy-adjusted DASH Index and the Vegetarian Lifestyle Index was associated with a 30%, 30%, and 33% reduction in hsCRP levels, respectively. Smaller effects were seen with the other diet scores with a one-point increase in adherence resulting in a 19%, 22% and 16% reduction in hsCRP with HEIFA, MEDAS, erMedDiet scores, respectively. The lack of stronger associations between the novel markers of inflammation and diet scores may be due to confounding by COVID-19 infection and vaccination programs, which prevents any firm conclusion on the relationship between PAF, Lp-PLA<subscript>2</subscript> and healthy dietary patterns. Future research should aim to examine the relationship with these novel markers and healthy dietary patterns in a non-pandemic setting. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFLAMMATION prevention
C-reactive protein
BIOMARKERS
LIPOPROTEINS
RESEARCH
FOOD habits
MEDITERRANEAN diet
VEGETARIANISM
COVID-19
PHOSPHOLIPASES
CROSS-sectional method
MULTIPLE regression analysis
CARDIOVASCULAR diseases
DIETARY supplements
BLOOD platelet activation
DAIRY products
RESEARCH funding
DESCRIPTIVE statistics
DASH diet
HEALTH behavior
STATISTICAL correlation
BEHAVIOR modification
Subjects
Details
- Language :
- English
- ISSN :
- 17437075
- Volume :
- 20
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nutrition & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 171897782
- Full Text :
- https://doi.org/10.1186/s12986-023-00756-x