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Insufficiency of Mrpl40 disrupts testicular structure and semen parameters in a murine model.

Authors :
Ying Liu
Long-Long Fu
Hui-Zhong Xu
Yi-Ming Zheng
Wei-Xi Li
Guang-Hui Qian
Wen-Hong Lu
Hai-Tao Lv
Source :
Asian Journal of Andrology; Sep/Oct2023, Vol. 25 Issue 5, p627-631, 6p
Publication Year :
2023

Abstract

Approximately 31% of patients with 22q11.2 deletion syndrome (22q11.2DS) have genitourinary system disorders and 6% of them have undescended testes. Haploinsufficiency of genes on chromosome 22q11.2 might contribute to the risk of 22q11.2DS. In this study, we used mice with single-allele deletion in mitochondrial ribosomal protein L40 (Mrpl40+/-) as models to investigate the function of Mrpl40 in testes and spermatozoa development. The penetrance of cryptorchidism in Mrpl40+/- mice was found to be higher than that in wild-type (WT) counterparts. Although the weight of testes was not significantly different between the WT and Mrpl40+/- mice, the structure of seminiferous tubules and mitochondrial morphology was altered in the Mrpl40+/- mice. Moreover, the concentration and motility of spermatozoa were significantly decreased in the Mrpl40+/- mice. In addition, data-independent acquisition mass spectrometry indicated that the expression of genes associated with male infertility was altered in Mrpl40+/- testes. Our study demonstrated the important role of Mrpl40 in testicular structure and spermatozoa motility and count. These findings suggest that Mrpl40 is potentially a novel therapeutic target for cryptorchidism and decreased motility and count of spermatozoa. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1008682X
Volume :
25
Issue :
5
Database :
Complementary Index
Journal :
Asian Journal of Andrology
Publication Type :
Academic Journal
Accession number :
171868647
Full Text :
https://doi.org/10.4103/aja2022119