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Automated analysis of pen-on-paper spirals for tremor detection, quantification, and differentiation.
- Source :
- Annals of Movement Disorders; Jan-Apr2023, Vol. 6 Issue 1, p17-25, 9p
- Publication Year :
- 2023
-
Abstract
- OBJECTIVE: To develop an automated algorithm to detect, quantify, and differentiate between tremor using pen-on-paper spirals. METHODS: Patients with essential tremor (n = 25), dystonic tremor (n = 25), Parkinson’s disease (n = 25), and healthy volunteers (HV, n = 25) drew free-hand spirals. The algorithm derived the mean deviation (MD) and tremor variability from scanned images. MD and tremor variability were compared with 1) the Bain and Findley scale, 2) the Fahn–Tolosa–Marin tremor rating scale (FTM–TRS), and 3) the peak power and total power of the accelerometer spectra. Inter and intra loop widths were computed to differentiate between the tremor. RESULTS: MD was higher in the tremor group (48.9±26.3) than in HV (26.4±5.3; p < 0.001). The cut-off value of 30.3 had 80.9% sensitivity and 76.0% specificity for the detection of the tremor [area under the curve: 0.83; 95% confidence index (CI): 0.75, 0.91, p < 0.001]. MD correlated with the Bain and Findley ratings (rho = 0.491, p = 0 < 0.001), FTM–TRS part B (rho = 0.260, p = 0.032) and accelerometric measures of postural tremor (total power, rho = 0.366, p < 0.001; peak power, rho = 0.402, p < 0.001). Minimum Detectable Change was 19.9%. Inter loop width distinguished Parkinson’s disease spirals from dystonic tremor (p < 0.001, 95% CI: 54.6, 211.1), essential tremor (p = 0.003, 95% CI: 28.5, 184.9), or HV (p = 0.036, 95% CI: -160.4, -3.9). CONCLUSION: The automated analysis of pen-on-paper spirals generated robust variables to quantify the tremor and putative variables to distinguish them from each other. SIGNIFICANCE: This technique maybe useful for epidemiological surveys and follow-up studies on tremor. [ABSTRACT FROM AUTHOR]
- Subjects :
- STATISTICS
RESEARCH
CONFIDENCE intervals
ANALYSIS of variance
TASK performance
HANDWRITING
ACCELEROMETERS
DYSTONIA
MOVEMENT disorders
TREMOR
DRAWING
DESCRIPTIVE statistics
PARKINSON'S disease
SENSITIVITY & specificity (Statistics)
DATA analysis
RECEIVER operating characteristic curves
DATA analysis software
ALGORITHMS
Subjects
Details
- Language :
- English
- ISSN :
- 25903446
- Volume :
- 6
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Annals of Movement Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 171864528
- Full Text :
- https://doi.org/10.4103/aomd.aomd_50_22