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Mitochondrial Properties in Skeletal Muscle Fiber.

Authors :
Dong, Han
Tsai, Shih-Yin
Source :
Cells (2073-4409); Sep2023, Vol. 12 Issue 17, p2183, 38p
Publication Year :
2023

Abstract

Mitochondria are the primary source of energy production and are implicated in a wide range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplements. In addition to being a powerhouse, mitochondria evoke many functions in skeletal muscle, including regulating calcium and reactive oxygen species levels. A healthy mitochondria population is necessary for the preservation of skeletal muscle homeostasis, while mitochondria dysregulation is linked to numerous myopathies. In this review, we summarize the recent studies on mitochondria function and quality control in skeletal muscle, focusing mainly on in vivo studies of rodents and human subjects. With an emphasis on the interplay between mitochondrial functions concerning the muscle fiber type-specific phenotypes, we also discuss the effect of aging and exercise on the remodeling of skeletal muscle and mitochondria properties. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734409
Volume :
12
Issue :
17
Database :
Complementary Index
Journal :
Cells (2073-4409)
Publication Type :
Academic Journal
Accession number :
171855584
Full Text :
https://doi.org/10.3390/cells12172183