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Is urinary type IV collagen a good marker of early impairment of renal function in childhood cancer survivors?

Is urinary type IV collagen a good marker of early impairment of renal function in childhood cancer survivors?

Authors :
Jezierska, Michalina
Owczarzak, Anna
Stefanowicz, Joanna
Source :
Acta Haematologica Polonica; 2023, Vol. 54 Issue 4, p235-240, 6p
Publication Year :
2023

Abstract

Introduction: Nephrotoxicity, as a side effect of antineoplastic treatment, can occur in childhood cancer survivors (CCSs). It worsens their quality of life especially if it leads to chronic kidney disease (CKD). Collagen turnover is known to be disturbed in CKD. Urinary type IV collagen (U-Col4) is recognized as an exponent of extracellular matrix synthesis and degradation in glomeruli and is thus involved in this turnover. The purpose of this study was to evaluate the usefulness of U-Col4 in assessing early renal impairment in CCSs. Material and methods: Seventy-eight CCSs, without CKD, bilateral kidney tumors, congenital kidney defects, urinary tract infections and diabetes, at least one year after ending antineoplastic treatment, and aged 1--18 years, were divided into three groups: 1) patients after nephroblastoma treatment (n = 18); 2) patients after other solid tumors treatment (n = 42); and 3) patients after anti-hamatopoietic and lymphatic system proliferative treatment (n = 18). Concentrations of creatinine and cystatin C in serum, and of albumin, creatinine, N-acetyl-β-D-glucosaminidase (NAG), and U-Col4 in urine, were measured, and a general urine analysis was performed. The albumin-creatinine ratio (ACR), the urine U-Col4/creatinine ratio, the urine NAG/creatinine ratio and the estimated glomerular filtration rate were according to the Schwartz and the Filler equations were calculated. Results: We did not find any differences between the groups in the evaluated biochemical parameters. Weak negative correlations were found between U-Col4 and urine NAG/creatinine ratio (p = 0.02, R = --0.27) and ACR (p = 0.00, R = --0.39). Conclusions: Evaluation of the usefulness of U-Col4 in assessing early renal impairment in CCSs requires further study. CCSs should be monitored for potential complications of antineoplastic treatment, even many years after its completion. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00015814
Volume :
54
Issue :
4
Database :
Complementary Index
Journal :
Acta Haematologica Polonica
Publication Type :
Academic Journal
Accession number :
171668361
Full Text :
https://doi.org/10.5603/AHP.a2023.0038ISSN0001-5814