A state-dependent M/M/1 queueing location-allocation model for vaccine distribution using metaheuristic algorithms.

Controlling and maintaining public health in the face of diseases necessitates the effective implementation of response strategies, including the distribution of vaccines. By distributing vaccines, vulnerable populations can be targeted, individuals can be protected, and the spread of diseases can be minimized. However, managing vaccine distribution poses challenges that require careful consideration of various factors, including the location of distribution facilities. This paper proposes a novel model that combines locationallocation problems with queueing systems methodologies to optimize the efficiency of vaccine distribution. The proposed model considers factors such as uncertain demand, varying service rates, depending on the system state. Its primary objective is to minimize total costs, which encompass the establishment and adjustment of the service mechanism, travel times, and customer waiting time. To forecast customer demand rates, the model utilizes time-series techniques, specifically the seasonal Autoregressive Integrated Moving Average model. In order to tackle large-scale problems, a total of 16 newly developed metaheuristic algorithms are employed, and their performance is thoroughly evaluated. This approach facilitates the generation of solutions that are nearly optimal within a reasonable timeframe. The effectiveness of the model is evaluated through a real-life case study focused on vaccination distribution in Iran. Furthermore, a comprehensive sensitivity analysis is conducted to demonstrate the practical applicability of the proposed model. The study contributes to the advancement of robust decision-making frameworks and provides valuable insights for addressing location-related challenges in health systems [ABSTRACT FROM AUTHOR]