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Clinicopathological Characteristics and Prognosis of Diffuse Large B-Cell Lymphoma in Relation to CA-125 and CA 19-9 Expression.
- Source :
- Journal of Evidence-Based Integrative Medicine; 8/31/2023, p1-8, 8p
- Publication Year :
- 2023
-
Abstract
- Background: Some epithelial tumors express the carbohydrate antigen 125 (Cancer antigen-125, CA-125) and CA 19-9, especially ovarian and pancreatic tumors. Patients with non-Hodgkin lymphoma (NHL) were reported to have a close association between serum CA-125 levels and adverse prognostic factors with worse survival. We aimed to investigate CA-125 and 19-9 expression in nodal diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS) tissues using immunohistochemistry (IHC) and their relations to clinicopathological manifestations and patients' survival. Methods: 65 cases of DLBCL NOS were examined. A modified mechanical pencil tip was used to construct Manual Tissue Micro-array (TMA) blocks. Immunohistochemical staining for CA-125 and CA 19-9 was performed and scored semi-quantitatively. All relations were analyzed using established statistical methodologies. Results: Aberrant expression of CA 19-9 was detected in 12% of cases without any expression of CA-125. Moreover, 75% of the CA 19-9 positive cases were statistically significantly associated with anemia and performance status 1. Also, 75% of the CA 19-9 positive cases were females. Conclusions: CA 19-9 was aberrantly expressed in 12% of nodal DLBCL NOS cases and significantly related to anaemia and performance status but not to survival. In cases of DLBCL NOS, CA 19-9 expression cannot be considered an independent prognostic factor. CA-125 was not expressed in nodal DLBCL NOS tissues, necessitating re-evaluation studies. Therefore, it is advised to conduct more research to clarify the potential correlation between serum and tissue CA 19-9 levels and other clinic-pathological characteristics of nodal and extranodal DLBCL NOS patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- TISSUE arrays
STAINS & staining (Microscopy)
IMMUNOHISTOCHEMISTRY
LOG-rank test
B cell lymphoma
CANCER patients
GENE expression
SEX distribution
DESCRIPTIVE statistics
ANEMIA
SURVIVAL analysis (Biometry)
CHI-squared test
KAPLAN-Meier estimator
TUMOR markers
TUMOR antigens
PROGRESSION-free survival
DATA analysis software
OVERALL survival
Subjects
Details
- Language :
- English
- ISSN :
- 2515690X
- Database :
- Complementary Index
- Journal :
- Journal of Evidence-Based Integrative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 171338262
- Full Text :
- https://doi.org/10.1177/2515690X231198315