Further Recommendations for PKU Management -- Part II.

The article discusses followup screening tests for phenylketonuria in newborn infants. A urine test for phenylpyruvic acid and orthohydroxylphenylacetic acid is better than no followup testing. A blood test at 4 to 6 weeks of life if chromatographic methods are not used in the urine testing has distinct advantages over a urine FeCU or Phenistix test. Urine at 4 to 6 weeks examined by paper chromatography would reveal the presence of excess amounts of phenylalanine, and the method offers the advantage of examining the urine for other disorders characterized by aminoaciduria.