Electrochemical Benzylic C(sp3)–H Amidation via Ritter-Type Reaction in the Absence of External Mediator and Oxidant.

Keywords: electrochemical oxidation; benzylic C(sp 3)-H amidation; Ritter-type reaction; external mediator free; oxidant free; N -benzylamides EN electrochemical oxidation benzylic C(sp 3)-H amidation Ritter-type reaction external mediator free oxidant free N -benzylamides 2969 2978 10 08/31/23 20230915 NES 230915 Graph Amides are abundant in almost all living organisms, and the amide group is one of the most common and versatile functional groups in a number of peptides and proteins, [1] pharmaceuticals, [2] agrochemicals, [3] and fluorescent sensor, [6] etc. Electrochemical Benzylic C(sp³)-H Amidation via Ritter-Type Reaction in the Absence of External Mediator and Oxidant N -(1-(4'-Ethyl-[1,1'-biphenyl]-4-yl)ethyl)acetamide (3c) The product was purified by silica gel column chromatography with PE/EtOAc (1:1, v/v); white solid; yield: 61.5 mg (77%); mp 144-146 °C. N -(1-(4'-Methyl-[1,1'-biphenyl]-4-yl)ethyl)acetamide (3b) The product was purified by silica gel column chromatography with PE/EtOAc (1:1, v/v); white solid; yield: 59.1 mg (78%); mp 160-162 °C. [Extracted from the article]