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Additive Effects of Cyclic Peptide [R4W4] When Added Alongside Azithromycin and Rifampicin against Mycobacterium avium Infection.

Authors :
Kelley, Melissa
Sasaninia, Kayvan
Abnousian, Arbi
Badaoui, Ali
Owens, James
Beever, Abrianna
Kachour, Nala
Tiwari, Rakesh Kumar
Venketaraman, Vishwanath
Source :
Pathogens; Aug2023, Vol. 12 Issue 8, p1057, 13p
Publication Year :
2023

Abstract

Mycobacterium avium (M. avium), a type of nontuberculous mycobacteria (NTM), poses a risk for pulmonary infections and disseminated infections in immunocompromised individuals. Conventional treatment consists of a 12-month regimen of the first-line antibiotics rifampicin and azithromycin. However, the treatment duration and low antibiotic tolerability present challenges in the treatment of M. avium infection. Furthermore, the emergence of multidrug-resistant mycobacterium strains prompts a need for novel treatments against M. avium infection. This study aims to test the efficacy of a novel antimicrobial peptide, cyclic [R4W4], alongside the first-line antibiotics azithromycin and rifampicin in reducing M. avium survival. Colony-forming unit (CFU) counts were assessed after treating M. avium cultures with varying concentrations of cyclic [R4W4] alone or in conjunction with azithromycin or rifampicin 3 h and 4 days post-treatment. M. avium growth was significantly reduced 4 days after cyclic [R4W4] single treatment. Additionally, cyclic [R4W4]–azithromycin and cyclic [R4W4]–rifampicin combination treatments at specific concentrations significantly reduced M. avium survival 3 h and 4 days post-treatment compared with single antibiotic treatment alone. These findings demonstrate cyclic [R4W4] as a potent treatment method against M. avium and provide insight into novel therapeutic approaches against mycobacterium infections. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20760817
Volume :
12
Issue :
8
Database :
Complementary Index
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
170743270
Full Text :
https://doi.org/10.3390/pathogens12081057