Order out of disorder: Regulation of endonuclease activity during eukaryotic mismatch repair.

Keywords: DNA mismatch repair; endonuclease; intrinsically disordered region; MutL homologs EN DNA mismatch repair endonuclease intrinsically disordered region MutL homologs 1 2 2 08/29/23 20230901 NES 230901 The polymerases that copy DNA are very good at their job, pairing adenines with thymines and cytosines with guanines at breakneck speed. DNA mismatch repair, endonuclease, intrinsically disordered region, MutL homologs These steps rely on a precise choreography of protein-protein and protein-DNA interactions, powered by cycles of ATP binding and hydrolysis in several of the proteins.[1] Mismatch recognition is coupled to downstream events by homologs of the I Escherichia coli i MMR protein, MutL. [Extracted from the article]