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Alzheimer's Disease and Sex-Dependent Alterations in the Striatum: A Lesson from a Mouse Model.
- Source :
- Journal of Alzheimer's Disease; 2023, Vol. 94 Issue 4, p1377-1380, 4p
- Publication Year :
- 2023
-
Abstract
- In the last years, many clinical studies highlighted sex-specific differences in the pathophysiology of Alzheimer's disease (AD). The recent paper published in the Journal of Alzheimer's Disease shows the influence of sex on amyloid-β plaque deposition, behavior, and dopaminergic signaling in the 5xFAD mouse model of AD, with worse alterations in female mice. This commentary focuses on the importance of recognizing sex as a key variable to consider for a more precise clinical practice, with the challenge to develop sex-specific therapeutic interventions in neurodegenerative diseases such as AD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 94
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 169947112
- Full Text :
- https://doi.org/10.3233/JAD-230681