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Circulating biomarkers are associated with disease severity of chronic hand eczema and atopic dermatitis.
- Source :
- British Journal of Dermatology; Jul2023, Vol. 189 Issue 1, p114-124, 11p
- Publication Year :
- 2023
-
Abstract
- Background Although chronic hand eczema (CHE) is a highly prevalent and disabling skin disease, it is currently unknown if CHE is associated with systemic inflammation. Objectives To characterize the plasma inflammatory signature of CHE. Methods Using Proximity Extension Assay technology, we assessed 266 inflammatory and cardiovascular disease risk proteins in the plasma of 40 healthy controls, 57 patients with atopic dermatitis (AD) with active lesions, 11 with CHE and a history of AD (CHE<superscript>PREVIOUS_AD</superscript>), and 40 with CHE and no history of AD (CHE<superscript>NO_AD</superscript>). Filaggrin gene mutation status was also assessed. Protein expression was compared between groups and according to disease severity. Correlation analyses for biomarkers, and clinical- and self-reported variables, were performed. Results Very severe CHE<superscript>NO_AD</superscript> was associated with systemic inflammation when compared with controls. Levels of T helper (Th)2- and Th1-, general inflammation and eosinophil activation markers increased with severity of CHE<superscript>NO_AD</superscript>, primarily being significantly increased in very severe disease. Significant, positive correlations were found between markers from these pathways and severity of CHE<superscript>NO_AD</superscript>. Moderate-to-severe but not mild AD displayed systemic inflammation. The Th2 markers C-C motif chemokine (CCL)17 and CCL13 (also known as monocyte chemotactic protein 4) were the top differentially expressed proteins in both very severe CHE<superscript>NO_AD</superscript> and moderate-to-severe AD, showing a higher fold change and significance in AD. CCL17 and CCL13 levels further correlated positively with disease severity in both CHE<superscript>NO_AD</superscript> and AD. Conclusions Systemic Th2-driven inflammation is shared between very severe CHE with no history of AD, and moderate-to-severe AD, suggesting that Th2 cell targeting could be effective in several CHE subtypes. [ABSTRACT FROM AUTHOR]
- Subjects :
- ECZEMA
ATOPIC dermatitis
CHRONIC diseases
TH2 cells
BLOOD proteins
BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 00070963
- Volume :
- 189
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- British Journal of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 169875764
- Full Text :
- https://doi.org/10.1093/bjd/ljad110