Development of the Formulation of Antiseptics and Disinfectants based on Silver Nanoparticles.

The article deals with the issue of the use of antiseptic and disinfectants, without which almost no sphere of our life can currently do. The regulatory requirements for antiseptics and disinfectants are determined, the main of which are safety for humans and the environment and high activity against most known pathogenic microorganisms (bacteria, viruses, fungi). Currently, there is no agent that would have a long-term antiseptic effect, long-term storage stability, and a broad antimicrobial effect on known microorganisms, so the search for universal disinfectants continues. The possibility of replacing alcohol-containing antiseptics and disinfectants with agents containing silver nanoparticles as an active component, which act on the principle of inhibiting the vital function of bacteria, is shown. Innovative antiseptic and disinfectants have been developed and tested under laboratory conditions on the basis of the Nanotex preparation synthesized at the Institute of Chemical Chemistry of the Russian Academy of Sciences. The silver nanoparticles included in their composition have an antimicrobial effect in relation to representatives of gram-positive (Staphilococcus aurus) and gram-negative (Escherichia coli) microflora, as well as to fungal culture (Candida albicans). The stability of the developed compositions has been proven by the methods of visual observations, electron microscopy and dynamic light scattering. Spectra of freshly prepared and long-term stored solutions are given, as well as diagrams of particle size distribution. The almost complete coincidence of these spectra indicates the stability of the preparations over time. A comparative evaluation of the developed compositions in relation to known antimicrobial agents was carried out. It is noted that the Nanoteks synthesized by us is not inferior in antimicrobial activity to the action of known antiseptics, taken at a concentration 1–2 orders of magnitude higher. [ABSTRACT FROM AUTHOR]