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The association between frailty and the risk of medication‐related problems among community‐dwelling older adults in Europe.
- Source :
- Journal of the American Geriatrics Society; Aug2023, Vol. 71 Issue 8, p2485-2494, 10p
- Publication Year :
- 2023
-
Abstract
- Background: Studies revealed unidirectional associations between frailty and medication‐related problems (MRPs) among older adults. Less is known about the association between frailty and the risk of MRPs. We aimed to assess the bi‐directional association between frailty and the risk of MRPs in community‐dwelling older adults in five European countries. Methods: Participants were 1785 older adults in the population‐based Urban Health Centres Europe project. Repeated assessments were collected at baseline and one‐year follow‐up, including frailty, the risk of MRPs, and covariates. Linear regression analyses were conducted to examine the unidirectional associations. A cross‐lagged panel modeling was used to assess bi‐directional associations. Results: The unidirectional association between frailty at baseline and the risk of MRPs at follow‐up remained statistically significant after adjusting for covariates (β = 0.10, 95%CI:0.08, 0.13). The association between the risk of MRPs at baseline and frailty at follow‐up shows similar trends. The bi‐directional association was comparable with reported unidirectional associations, with a stronger effect from frailty at baseline to the risk of MRPs at follow‐up than reversed path (Wald test for comparing lagged effects: p < 0.05). Conclusion: This longitudinal study suggests that a cycle may exist where older adults with higher frailty levels are more likely to have a higher risk of MRPs, which in turn contributes to developing a higher level of frailty. Further research is needed to validate our findings and explore underlying pathways. [ABSTRACT FROM AUTHOR]
- Subjects :
- OBESITY
LIFESTYLES
FRAIL elderly
NUTRITIONAL assessment
RESEARCH methodology
SELF-evaluation
POLYPHARMACY
AGE distribution
GERIATRIC assessment
REGRESSION analysis
INTERVIEWING
MEDICATION errors
RISK assessment
URBAN hospitals
INAPPROPRIATE prescribing (Medicine)
T-test (Statistics)
SEX distribution
INDEPENDENT living
RESEARCH funding
QUESTIONNAIRES
DRUGS
EXERCISE
MALNUTRITION
DESCRIPTIVE statistics
CHI-squared test
ALCOHOL drinking
DRUG side effects
PATIENT compliance
BODY mass index
STATISTICAL models
DATA analysis software
SMOKING
LONGITUDINAL method
COMORBIDITY
EDUCATIONAL attainment
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00028614
- Volume :
- 71
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of the American Geriatrics Society
- Publication Type :
- Academic Journal
- Accession number :
- 169783528
- Full Text :
- https://doi.org/10.1111/jgs.18343