Construction of Difluoroalkylated Cyclopentenones through Photocatalytic Difluoroalkylative 5‐endo Cyclization Cascades of Ynones.

Difluoroalkyl groups and cyclopentenones are both important units in synthetic and medicinal chemistry. The difuoroalkylation coupled with a cyclopentenone formation still remains a challenge. Herein, we report a visible‐light‐induced cascade difluoroalkylative 5‐endo cyclization of ynones with difluoroalkyl bromides to access difluoroalkylated cyclopentenones, which may find wide applications for the concise synthesis of fluorinated cyclic molecules. [ABSTRACT FROM AUTHOR]