In vitro cytotoxicity of Mn(I) and Ru(II) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia.

Authors :: Mansour, Ahmed M.
Khaled, Rabaa M.
Radacki, Krzysztof
Younes, Zeina
Gamal, Mariam
Guirguis, Beatrice
Mostafa, Gamal A. E.
Ali, Essam A.
Shehab, Ola R.
Source :: Dalton Transactions: An International Journal of Inorganic Chemistry; 8/14/2023, Vol. 52 Issue 30, p10286-10293, 8p
Publication Year :: 2023
Abstract: Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(I) and Ru(II) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(II) complex (IC<subscript>50</subscript> = 7.13 ± 0.8 μM) displayed higher outstanding potency against leukaemia than the Mn(I) analogue (54.58 ± 4.1 μM) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells. [ABSTRACT FROM AUTHOR]

Subjects :: LEUKEMIA
DIPHENYL
BONE marrow cells
ACUTE leukemia
PHOSPHINE
RUTHENIUM compounds

Language :: English
ISSN :: 14779226
Volume :: 52
Issue :: 30
Database :: Complementary Index
Journal :: Dalton Transactions: An International Journal of Inorganic Chemistry
Publication Type :: Academic Journal
Accession number :: 169706515
Full Text :: https://doi.org/10.1039/d3dt01798b

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