Metabolic parameters are food-entrained in rats made cirrhotic by chronic CCl4 treatment.

Food entrainment of clock genes in peripheral tissues and anticipatory response in the liver of rats maintained under a restricted feeding schedule have suggested that the liver may be a relevant element for a food entrained oscillator (FEO). Recent data suggest that mechanisms underlying food-entrainment for metabolic and behavioral or locomotor food anticipatory activity may depend on different regulatory systems. In a previous study we reported that a dysfunctional liver does not prevent animals from exhibiting behavioral anticipatory activity associated with restricted feeding schedules (RFS). The present study aimed to determine whether in CCl4 cirrhotic rats metabolic parameters are entrained to RFS. Chronic CCl4 treated cirrhotic rats and oil treated controls were entrained to RFS. After 2 weeks, rats were sacrificed 2 and 0?h before and 2 and 4?h after mealtime. Serum glucose and free fatty acids were determined as well as liver glycogen. Both groups exhibited a similar entrained pattern in the three parameters. Thus we conclude that anatomical and functional alterations produced by chronic administration of CCl4 do not interfere with entrainment of metabolic parameters to RFS and point out the relevance of other mechanisms independent of the liver to drive peripheral food entrained rhythms. [ABSTRACT FROM AUTHOR]