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Anxiety-like Behavior in Female Sprague Dawley Rats Associated with Cecal Clostridiales.
- Source :
- Microorganisms; Jul2023, Vol. 11 Issue 7, p1773, 23p
- Publication Year :
- 2023
-
Abstract
- The relationship between the microbiota profile and exposure to stress is not well understood. Therefore, we used a rat model of unpredictable chronic mild stress (UCMS) to investigate this relationship. Depressive-like behaviors were measured in Female Sprague Dawley rats using the sucrose preference test and the Porsolt swim test. Anxiety-like behaviors were measured with the light–dark box test. Fecal corticosterone, cecal microbiota (composition and organic acids), plasma gut permeability (lipopolysaccharide-binding protein, LBP) and plasma inflammation (12 cytokines) markers were measured. Atypical behaviors were observed in female rats following UCMS, but no depressive-like behaviors were observed. Circulating concentrations of cytokines granulocyte-macrophage colony-stimulating factor and cytokine-induced neutrophil chemoattractant 1 were higher in UCMS-exposed female rats; plasma LBP and cecal organic acid levels remained unchanged. Our results reflect a resilient and adaptive phenotype for female SD rats. The relative abundance of taxa from the Clostridiales order and Desulfovibrionaceae family did, however, correlate both positively and negatively with anxiety-like behaviors and plasma cytokine concentrations, regardless of UCMS exposure, supporting the brain-to-gut influence of mild anxiety with a microbiota profile that may involve inflammatory pathways. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20762607
- Volume :
- 11
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Microorganisms
- Publication Type :
- Academic Journal
- Accession number :
- 169332574
- Full Text :
- https://doi.org/10.3390/microorganisms11071773