Back to Search
Start Over
Exploring the natural history of intrinsic capacity impairments: longitudinal patterns in the 10/66 study.
- Source :
- Age & Ageing; Jul2023, Vol. 52 Issue 7, p1-9, 9p, 1 Diagram, 2 Charts, 1 Graph
- Publication Year :
- 2023
-
Abstract
- Background intrinsic capacity (IC) is a construct encompassing people's physical and mental abilities. There is an implicit link amongst IC domains: cognition, locomotion, nutrition, sensory and psychological. However, little is known about the integration of the domains. Objectives to investigate patterns in the presentation and evolution of IC domain impairments in low-and-middle-income countries and if such patterns were associated with adverse outcomes. Methods secondary analyses of the first two waves of the 10/66 study (population-based surveys conducted in eight urban and four rural catchment areas in Cuba, Dominican Republic, Puerto Rico, Venezuela, Peru, Mexico and China). We applied latent transition analysis on IC to find latent statuses (latent clusters) of IC domain impairments. We evaluated the longitudinal association of the latent statuses with the risk of frailty, disability and mortality, and tested concurrent and predictive validity. Results amongst 14,923 participants included, the four latent statuses were: high IC (43%), low deterioration with impaired locomotion (17%), high deterioration without cognitive impairment (22%), and high deterioration with cognitive impairment (18%). A total of 61% of the participants worsened over time, 35% were stable, and 3% improved to a healthier status. Participants with deteriorated IC had a significantly higher risk of frailty, disability and dementia than people with high IC. There was strong concurrent and predictive validity. (Mortality Hazard Ratio = 4.60, 95%CI 4.16; 5.09; Harrel's C = 0.73 (95%CI 0.72;0.74)). Conclusions half of the study population had high IC at baseline, and most participants followed a worsening trend. Four qualitatively different IC statuses or statuses were characterised by low and high levels of deterioration associated with their risk of disability and frailty. Locomotion and cognition impairments showed other trends than psychological and nutrition domains across the latent statuses. [ABSTRACT FROM AUTHOR]
- Subjects :
- COMPETENCY assessment (Law)
DEMENTIA risk factors
MORTALITY risk factors
COGNITION disorders
WALKING speed
MIDDLE-income countries
FRAIL elderly
CONFIDENCE intervals
RESEARCH methodology evaluation
HEALTH status indicators
HEALTH outcome assessment
RISK assessment
LOW-income countries
DESCRIPTIVE statistics
PREDICTIVE validity
SECONDARY analysis
LATENT structure analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00020729
- Volume :
- 52
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Age & Ageing
- Publication Type :
- Academic Journal
- Accession number :
- 169328725
- Full Text :
- https://doi.org/10.1093/ageing/afad137