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C-Reactive Protein Levels and Cognitive Decline following Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Authors :
Wang, Likun
Yang, Lining
Liu, Haiyan
Pu, Juncai
Li, Yi
Tang, Lu
Chen, Qing
Pu, Fang
Bai, Dingqun
Source :
Brain Sciences (2076-3425); Jul2023, Vol. 13 Issue 7, p1082, 12p
Publication Year :
2023

Abstract

Cognitive decline (CD) is devastating with a high incidence in patients after stroke. Although some studies have explored underlying associations between C-reactive protein (CRP) levels and cognitive decline after stroke, consistent results have not been obtained. Therefore, this meta-analysis aimed to explore whether or not higher levels of C-reactive proteins were associated with an increased risk of cognitive decline after stroke. To this end, PubMed, Embase, the Cochrane Library, and Web of Science were searched for eligible studies, and pooled effect sizes from eligible studies were calculated using random effect models. Furthermore, subgroups were established and meta-regression analyses were performed to explain the causes of heterogeneity. Eventually, nine studies with 3893 participants were included. Our statistical results suggested that the concentrations of peripheral CRP may be significantly increased for CD patients after stroke, compared to those of non-CD patients. Subgroup analyses showed that CRP was higher in CD than that in non-CD patients when the mini-mental state examination was used. A higher level of CRP in the acute phase of ischemic stroke may suggest an increased risk of CD after stroke. However, these results should be cautiously interpreted because of the limited sample sizes and the diversity of potential confounders in the studies included in this meta-analysis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20763425
Volume :
13
Issue :
7
Database :
Complementary Index
Journal :
Brain Sciences (2076-3425)
Publication Type :
Academic Journal
Accession number :
168601028
Full Text :
https://doi.org/10.3390/brainsci13071082