The Upper Limb-Cardiovascular Syndrome (Holt-Oram Syndrome).

Two syndromes with coexisting cardiac and bone malformations have been identified.' In ventrkuloradinl dysplasia, congenital alterations of the radius occur together with ventricular septal defect.² The Holl-Oram syndrome consists of atrial septal defect, cardiac arrthymias, and nialforinations of one or both thumbs.³ This report describes four cases of the Holt-Oram syndrome studied at the Instituto Nacional de Cardiologia de Mexico. [ABSTRACT FROM AUTHOR]