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Consequences of HIV infection in the bone marrow niche.
- Source :
- Frontiers in Immunology; 2023, p1-17, 17p
- Publication Year :
- 2023
-
Abstract
- Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular environment which functions primarily in the maintenance of haematopoietic stem/progenitor cells (HSPCs). These adult stem cells are responsible for replacing blood and immune cells over the course of a lifetime. Cells of the bone marrow niche support HSPCs and help to orchestrate the quiescence, self-renewal and differentiation of HSPCs through chemical and molecular signals and cell-cell interactions. This narrative review discusses the HIV-associated dysregulation of the bone marrow niche, as well as the susceptibility of HSPCs to infection by HIV. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV infections
BONE marrow
BONE marrow cells
BLOOD cells
CELL communication
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 167446290
- Full Text :
- https://doi.org/10.3389/fimmu.2023.1163012