Gallbladder Carcinoma with Biliary Invasion: Clinical Analysis of the Differences from Nonbiliary Invasion.

Gallbladder carcinoma is the most common malignancy of the biliary tract. Because of a lack of specific presentations, this condition frequently is diagnosed only at an advanced stage. The clinical difference between gallbladder carcinoma with and without biliary involvement remains uncertain. This study recruited all patterns with gallbladder car- cinoma treated at Chang Gung Memorial Hospital (Taoyuan,Taiwan) from 1987 to 2002. The sample included 120 patients aged 28 to 91 years (mean 65.5 ± 12.3 years) (39 men, 81 women), whose medical records men reviewed retrospectively. Based on the 2002 newly revised TNM classification, 25, 38, 28, and 29 patients bad stage I, II, III, and IV disease, respectively. After we excluded patients with stage I, the other patients were classified into two groups us follows: group I, gallbladder carcinoma with biliary invasion (n = 41); group II, carcinoma without biliary involvement (n = 54). The clinical presentations, laboratory data, operative methods, and outcome of these two groups were compared. The two groups did not differ in terms of age, sex distribution, cholelithiasis, and most clinical presentations. Chemistry laboratory data also identified patients in group I with significantly elevated liver function tests. Group [I had a borderline tendency toward better curative resectability than group I (p = 0.09). Survival was significantly better for group I patients who underwent curative resection (n = 5) via cholecystectomy, partial hepatectomy, and bile duct resection than for those with noncurative resection (p < 0.05). However, long-term survival demonstrated that gallbladder carcinoma bad the same poor prognosis in the two groups. In conclusion, gallbladder carcinoma with biliary invasion has been found to a more overt clinical presentation and abnormal laboratory data, which might alert clinicians to consider gallbladder carcinoma at an advanced stage or biliary invasion and examine the underlying disease. Generally, the outcome of gallbladder carcinoma is dismal, and radical curative resection the combined with cholecystectomy, partial hepatectomy, and bile duct resection perhaps may offer good benefits for advanced gall- bladder carcinoma. Furthermore, surgical resection should be performed whenever possible in patients with gallbladder carcinoma to increase life expectancy. [ABSTRACT FROM AUTHOR]