Researchers from Guangzhou University of Chinese Medicine Detail Findings in Osteosarcomas (Baicalin Induces Ferroptosis In Osteosarcomas Through a Novel Nrf2/xct/ Gpx4 Regulatory Axis).

The news reporters obtained a quote from the research from the Guangzhou University of Chinese Medicine, "Baicalin, a major bioactive flavone derived from traditional Chinese medicine Scutellaria baicalensis, has been proved to have anti-tumor properties in OS. Keywords: Guangzhou; People's Republic of China; Asia; Cancer; Drugs and Therapies; Glutathione; Health and Medicine; Oligopeptides; Oncology; Osteosarcomas; Peptides EN Guangzhou People's Republic of China Asia Cancer Drugs and Therapies Glutathione Health and Medicine Oligopeptides Oncology Osteosarcomas Peptides 1071 1071 1 07/31/23 20230801 NES 230801 2023 JUL 31 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Data detailed on Oncology - Osteosarcomas have been presented. By promoting the Fe accumulation, ROS formation, MDA production and suppressing the ratio of GSH/ GSSG, baicalin was found to trigger ferroptosis in OS and ferroptosis inhibitor ferrostatin-1 (Fer-1) successfully reversed these suppressive effects, indicating that ferroptosis participated in the baicalin mediated anti-OS ac-tivity. [Extracted from the article]