Characterization of signaling pathways leading to Fas expression induced by TNF-α: pivotal role of NF-κB.

Investigates the signal transduction mechanisms involved in Fas induction. Pretreatment of Sertoli cells with specific inhibitors of ERKs and P38 at all concentrations tested; Regulation of Fas expression to avoid indiscriminate cell death; Significance of understanding the molecular mechanisms activated by cytokines.