Abstract Supplement Abstracts from IAS 2023, the 12th IAS Conference on HIV Science, 23 – 26 July, Brisbane, Australia & Virtual.

OAA0304 Hypoxic adaptation uncovers a glycolytic dependence of HIV-1 latency reversal Y.I. Kayode SP 1 sp , D.C. Clemmer SP 1 sp , A.A. Owolabi SP 1 sp , L.M. Clark SP 1 sp , H.E. Taylor SP 1 sp SP 1 sp SUNY Upstate Medical University, Microbiology and Immunology, Syracuse, United States B Background b : The main barrier to HIV-1 curative strategies is the persistence of latently infected CD4 T cells in lymphoid tissue compartments which readily fuel viral rebound following antiretroviral therapy (ART) interruption in people living with HIV (PLWH). Mamba SP 1 sp , V. Williams SP 1 sp , A. Mafukidze SP 1 sp , P. Bongomin SP 1 sp , P. Dlamini SP 1 sp , G. Mchunu SP 1 sp , S. Mhlanga SP 1 sp , H. Byarugaba SP 1 sp , J. Opoku SP 2 sp , S. Kibwana SP 3 sp , S. Ojoo SP 2 sp , D. Bazira SP 2 sp , S. Haumba SP 1 sp SP 1 sp Center for Global Health Practice and Impact, Georgetown University, Mbabane, Eswatini, SP 2 sp Center for Global Health Practice and Impact, Georgetown University Medical Center, Washington DC, United States, SP 3 sp Center for Global Health Practice and Impact, Georgetown University Medical Center, Washington, United States B Background b : Pill count is widely used as an adherence measure among clients taking antiretroviral therapy (ART). OAA0102 Resident microbiota enhance HIV acquisition, replication and pathogenesis in vivo A. Wahl SP 1 sp , W. Yao SP 1 sp , B. Liao SP 1 sp , M. Chateau SP 1 sp , C. Richardson SP 1 sp , L. Ling SP 1 sp , J. Tucker SP 1 sp , I. McGowan SP 2 sp , R.B. Sartor SP 1 sp , J.V. Garcia SP 1 sp SP 1 sp University of North Carolina at Chapel Hill, Chapel Hill, United States, SP 2 sp University of Pittsburgh Medical School, Pittsburgh, United States B Background b : Resident microbiota maintain intestinal homeostasis by regulating digestion, metabolism, immune development and providing protection from infection. [Extracted from the article]