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Differential associations of clinical features with cerebrospinal fluid biomarkers in dementia with Lewy bodies and Alzheimer's disease.
- Source :
- Aging Clinical & Experimental Research; Aug2023, Vol. 35 Issue 8, p1741-1752, 12p
- Publication Year :
- 2023
-
Abstract
- Aim: To explore associations of cerebrospinal fluid biomarkers of neurodegeneration and amyloidosis with caregiver burden, cognition and functionality in dementia with Lewy bodies (DLB) paired with late-onset Alzheimer's disease (AD) and healthy older people. Methods: Consecutive outpatients with DLB were matched with outpatients with AD according to sex, cognitive scores and dementia stage, and with cognitively healthy controls according to age and sex to investigate associations of cerebrospinal fluid amyloid-β (Aβ<subscript>42</subscript>,Aβ<subscript>40</subscript>,Aβ<subscript>38</subscript>), tau, phospho-tau Thr<subscript>181</subscript>, ubiquitin, α-synuclein and neurofilament light with caregiver burden, functionality, reverse digit span, a clock drawing test, Mini-Mental State Examination (MMSE) and Severe MMSE, adjusted for sex, age, education, dementia duration and APOE-ε4 alleles. Results: Overall, 27 patients with DLB (78.98 ± 9.0 years-old; eleven APOE-ε4 +) were paired with 27 patients with AD (81.50 ± 5.8 years-old; twelve APOE-ε4 +) and 27 controls (78.98 ± 8.7 years-old; four APOE-ε4 +); two-thirds were women. In AD, Aβ<subscript>42</subscript>/Aβ<subscript>38</subscript> and Aβ<subscript>42</subscript> were lower, while tau/Aβ<subscript>42</subscript> and phospho-tau Thr<subscript>181</subscript>/Aβ<subscript>42</subscript> were higher; α-synuclein/Aβ<subscript>42</subscript> was lower in DLB and higher in AD. The following corrected associations remained significant: in DLB, instrumental functionality was inversely associated with tau/phospho-tau Thr<subscript>181</subscript> and tau/Aβ<subscript>42</subscript>, and reverse digit span associated with α-synuclein; in AD, instrumental functionality was inversely associated with neurofilament light, clock drawing test scores inversely associated with phospho-tau Thr<subscript>181</subscript>/Aβ<subscript>42</subscript> and α-synuclein/Aβ<subscript>42</subscript>, and Severe MMSE inversely associated with tau/Aβ<subscript>42</subscript> and tau/phospho-tau Thr<subscript>181</subscript>. Conclusions: Cerebrospinal fluid phospho-tau Thr<subscript>181</subscript> in DLB was similar to AD, but not Aβ<subscript>42</subscript>. In associations with test scores, biomarker ratios were superior to isolated biomarkers, while worse functionality was associated with axonal degeneration only in AD. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOMARKERS
AMYLOID
RESEARCH
LEWY body dementia
ALZHEIMER'S disease
AMYLOIDOSIS
NERVE tissue proteins
AGE distribution
TAU proteins
CROSS-sectional method
BURDEN of care
GERIATRIC assessment
ALLELES
ACTIVITIES of daily living
RISK assessment
COMPARATIVE studies
DEMENTIA patients
SEX distribution
NEUROPSYCHOLOGICAL tests
SYMPTOMS
RESEARCH funding
PSYCHOLOGY of caregivers
DESCRIPTIVE statistics
APOLIPOPROTEINS
SYNUCLEINS
COGNITIVE testing
STATISTICAL correlation
CYTOPLASM
Subjects
Details
- Language :
- English
- ISSN :
- 15940667
- Volume :
- 35
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Aging Clinical & Experimental Research
- Publication Type :
- Academic Journal
- Accession number :
- 165465395
- Full Text :
- https://doi.org/10.1007/s40520-023-02452-5