Ефективність місцевого лікування ВПЛ-асоційованої патології шийки матки у жінок за допомогою вагінального гелю на основі Coriolus versicolor.

Human papillomavirus (HPV) is one of the most common groups of viruses. Almost all sexually active people can be included in the risk group of HPV infection. Numerous studies indicate a significant prevalence of HPV with a high oncogenic risk, especially among women under 30 years of age. The course of HPV depends on the state of the immune system and can be transient, latent or persistent. A significant role belongs to the state of local immunity and vaginal microbiota. Long-term persistence of HPV in the tissues of the lower part of the genital tract organs provokes the development of precancer and cancer processes. The objective: to evaluate the effectiveness of a vaginal gel based on Coriolus versicolor in the treatment of low-grade cervical lesions caused by HPV. Materials and methods. This study involved 91 HPV-positive women with low-grade pap smear lesions who had regular colposcopy. Women were randomized (in a 1:1:1 ratio) to three treatment groups: A treatment, B treatment, and a control group (expectant approach). Results. Since the state of the immune system largely determines the course of HPV infection, the modern approach to the treatment of HPV-associated diseases involves the use of local intravaginal antiviral and immunomodulatory therapy, which promotes the elimination of pathogens and ensures full epithelization of the cervix, reducing the frequency of recurrence, which preserves women’s reproductive health. The percentage of patients with a normal Pap smear and serial colposcopy in 6 months was significantly higher in the treatment group than in the control group (84.9% vs. 64.5%, respectively; p=0.031; this difference was even more prominent in the high-risk subgroup of HPV-infected women (87.8% vs. 56.0% for the treatment and control groups, respectively; p=0.003). Significant differences were also observed at 3 months in the overall sample of patients (78.0% vs. 54.8% for the treatment and control groups, respectively; p=0.023) and the subgroup of high-risk HPV-infected women (79.5% vs. 52 .0%, respectively; p=0.017). Conclusions. Treatment with a Coriolus versicolor vaginal gel has demonstrated greater clinical benefit than a standard expectant approach in clinical practice for patients with total and high risk of HPV infection for the treatment efficacy of HPVrelated cervical lesions and removal of all HPV strains from the organism after one six-month period. [ABSTRACT FROM AUTHOR]