Seizing the Opportunity to Improve Ethical Oversight of Clinical Research.

The author comments on the article "Think Pragmatically: Investigators' Obligations to Patient-Subjects When Research Is Embedded in Care" by Stephanie Morain and Emily Largent which argue that investigators and possibly institutions have distinct ethical duties when conducting or participating in pragmatic trials. Topics include their arguments that there are at least six morally significant differences between explanatory and pragmatic trials and their suggestion to avoid a fiduciary framing.