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Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation.
- Source :
- Science Immunology; 2017, Vol. 2 Issue 13, p1-12, 12p, 7 Graphs
- Publication Year :
- 2017
-
Abstract
- Specific gut commensal bacteria improve host health by eliciting mutualistic regulatory T (T<subscript>reg</subscript>) cell responses. However, the bacteria that induce effector T (T<subscript>eff</subscript>) cells during inflammation are unclear. We addressed this by analyzing bacterial-reactive T cell receptor (TCR) transgenic cells and TCR repertoires in a murine colitis model. Unexpectedly, we found that mucosal-associated Helicobacter species triggered both T<subscript>reg</subscript> cell responses during homeostasis and T<subscript>eff</subscript> cell responses during colitis, as suggested by an increased overlap between the T<subscript>eff</subscript>/T<subscript>reg</subscript> TCR repertoires with colitis. Four of six T<subscript>reg</subscript> TCRs tested recognized mucosal-associated Helicobacter species in vitro and in vivo. By contrast, the marked expansion of luminal Bacteroides species seen during colitis did not trigger a commensurate T<subscript>eff</subscript> cell response. Unlike other T<subscript>reg</subscript> cell–inducing bacteria, Helicobacter species are known pathobionts and cause disease in immunodeficient mice. Thus, our study suggests a model in which mucosal bacteria elicit context-dependent T<subscript>reg</subscript> or T<subscript>eff</subscript> cell responses to facilitate intestinal tolerance or inflammation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 24709468
- Volume :
- 2
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Science Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 164971049
- Full Text :
- https://doi.org/10.1126/sciimmunol.aal5068