Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity.

Authors :: Alguacil, Andrés
Scalambra, Franco
Lorenzo-Luis, Pablo
Puerta, Adrián
González-Bakker, Aday
Mendoza, Zenaida
Padrón, José M.
Romerosa, Antonio
Source :: Dalton Transactions: An International Journal of Inorganic Chemistry; 7/28/2023, Vol. 52 Issue 28, p9541-9545, 5p
Publication Year :: 2023
Abstract: Complexes [{RuCp(PPh<subscript>3</subscript>)<subscript>2</subscript>-μ-dmoPTA-1κP:2κ<superscript>2</superscript>-N,N′-CuCl}<subscript>2</subscript>-μ-Cl-μ-OCH<subscript>3</subscript>](CF<subscript>3</subscript>SO<subscript>3</subscript>)<subscript>2</subscript>·(CH<subscript>3</subscript>OH)<subscript>4</subscript> (1) and [{RuCp(PPh<subscript>3</subscript>)<subscript>2</subscript>-μ-dmoPTA-1κP:2κ<superscript>2</superscript>-N,N′-NiCl}<subscript>2</subscript>-μ-Cl-μ-OH](CF<subscript>3</subscript>SO<subscript>3</subscript>)<subscript>2</subscript> (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI<subscript>50</subscript> values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated. [ABSTRACT FROM AUTHOR]

Language :: English
ISSN :: 14779226
Volume :: 52
Issue :: 28
Database :: Complementary Index
Journal :: Dalton Transactions: An International Journal of Inorganic Chemistry
Publication Type :: Academic Journal
Accession number :: 164957826
Full Text :: https://doi.org/10.1039/d3dt01284k